Vanderbilt study looks at benefits of progestogens to prevent early childbirthPublic release date: 10-Sep-2012 [ | E-mail | Share ]
Contact: Craig Boerner craig.boerner@vanderbilt.edu 615-322-4747 Vanderbilt University Medical Center
Pregnant women who have had prior preterm births may avoid a subsequent early birth if given progestogens, which are natural or synthetic forms of progesterone, a female hormone that naturally increases during pregnancy, a Vanderbilt analysis shows.
Women who have had prior preterm births and are given progestogens while expecting a single child show some benefit from additional hormone, Vanderbilt researchers reported in a systematic review released on Thursday in Obstetrics & Gynecology, the official publication of the American College of Obstetricians and Gynecologists, commonly referred to as The Green Journal.
The researchers looked at 34 prior studies of women who were given progestogens for prior preterm births, multiple gestations, preterm labor, short cervix or other indications. Each study included 20 or more women who were given the medication by injection, orally or vaginally, and took place between January 1966 and October 2011.
The work was funded by the Agency for Healthcare Research and Quality (AHRQ).
In contrast, the researchers found progestogens don't seem to help prevent preterm labor in women carrying twins or triplets. And evidence supporting giving progestogens for all other uses is insufficient to guide clinical care.
The review provides valuable information, but more study is needed, said Frances E. Likis, DrPH, N.P., CNM, research assistant professor of Medicine and the lead author of the review. "While we know that women have progesterone levels that go up in early pregnancy and remain elevated, we still don't understand why giving extra progestogens would help them stay pregnant," she said. "The pharmaceutical effects are not well understood."
The United States has a very high preterm birth rate and was among the top 10 countries with the highest numbers of preterm births in 2010. "We haven't been able to move that number very well, and although it's gone down somewhat in past years, it's not a dramatic drop," she said.
Along with the systematic review, the AHRQ is releasing Vanderbilt's longer report on progestogens for preterm birth prevention online today. The full report looks at other questions such as whether how progestogens are administered makes a difference in effectiveness and the adverse effects of progestogens for preterm birth.
Progestogens are usually given by clinicians to women at the beginning of the second trimester through 37 weeks gestation or until the baby is born. Most women receive the medication once a week by injection, although some receive it vaginally. Very few take an oral dose.
Likis said asking generally whether progestogens are beneficial isn't possible.
"Women are being given progestogens for very different reasons, so in our review, we decided to look at effectiveness by why women took it. Having had a previous preterm birth is different from having twins, and that's how clinicians make decisions. They don't just look at women and say 'you're at risk,' they say 'what is your risk factor?'"
To look at complications, a larger group of women is needed, she said.
"There's relatively little evidence about whether babies had complications, and there's also very little information about long-term health effects in the infant," she said. "There's a lot more that needs to be studied. There's a lot of work to be done."
###
In addition to Likis, the Vanderbilt team included Digna R. Velez Edwards, Ph.D., Jeffrey C. Andrews, M.D., Alison L. Woodworth, Ph.D., Rebecca N. Jerome, MLIS, MPH, Christopher J. Fonnesbeck, Ph.D., Nikki McKoy, MPH, and Katherine E. Hartmann, M.D., Ph.D.
The full report can be viewed at www.ahrq.gov.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Vanderbilt study looks at benefits of progestogens to prevent early childbirthPublic release date: 10-Sep-2012 [ | E-mail | Share ]
Contact: Craig Boerner craig.boerner@vanderbilt.edu 615-322-4747 Vanderbilt University Medical Center
Pregnant women who have had prior preterm births may avoid a subsequent early birth if given progestogens, which are natural or synthetic forms of progesterone, a female hormone that naturally increases during pregnancy, a Vanderbilt analysis shows.
Women who have had prior preterm births and are given progestogens while expecting a single child show some benefit from additional hormone, Vanderbilt researchers reported in a systematic review released on Thursday in Obstetrics & Gynecology, the official publication of the American College of Obstetricians and Gynecologists, commonly referred to as The Green Journal.
The researchers looked at 34 prior studies of women who were given progestogens for prior preterm births, multiple gestations, preterm labor, short cervix or other indications. Each study included 20 or more women who were given the medication by injection, orally or vaginally, and took place between January 1966 and October 2011.
The work was funded by the Agency for Healthcare Research and Quality (AHRQ).
In contrast, the researchers found progestogens don't seem to help prevent preterm labor in women carrying twins or triplets. And evidence supporting giving progestogens for all other uses is insufficient to guide clinical care.
The review provides valuable information, but more study is needed, said Frances E. Likis, DrPH, N.P., CNM, research assistant professor of Medicine and the lead author of the review. "While we know that women have progesterone levels that go up in early pregnancy and remain elevated, we still don't understand why giving extra progestogens would help them stay pregnant," she said. "The pharmaceutical effects are not well understood."
The United States has a very high preterm birth rate and was among the top 10 countries with the highest numbers of preterm births in 2010. "We haven't been able to move that number very well, and although it's gone down somewhat in past years, it's not a dramatic drop," she said.
Along with the systematic review, the AHRQ is releasing Vanderbilt's longer report on progestogens for preterm birth prevention online today. The full report looks at other questions such as whether how progestogens are administered makes a difference in effectiveness and the adverse effects of progestogens for preterm birth.
Progestogens are usually given by clinicians to women at the beginning of the second trimester through 37 weeks gestation or until the baby is born. Most women receive the medication once a week by injection, although some receive it vaginally. Very few take an oral dose.
Likis said asking generally whether progestogens are beneficial isn't possible.
"Women are being given progestogens for very different reasons, so in our review, we decided to look at effectiveness by why women took it. Having had a previous preterm birth is different from having twins, and that's how clinicians make decisions. They don't just look at women and say 'you're at risk,' they say 'what is your risk factor?'"
To look at complications, a larger group of women is needed, she said.
"There's relatively little evidence about whether babies had complications, and there's also very little information about long-term health effects in the infant," she said. "There's a lot more that needs to be studied. There's a lot of work to be done."
###
In addition to Likis, the Vanderbilt team included Digna R. Velez Edwards, Ph.D., Jeffrey C. Andrews, M.D., Alison L. Woodworth, Ph.D., Rebecca N. Jerome, MLIS, MPH, Christopher J. Fonnesbeck, Ph.D., Nikki McKoy, MPH, and Katherine E. Hartmann, M.D., Ph.D.
The full report can be viewed at www.ahrq.gov.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
I think that all hunters know which are the new tipes of pets that MoP will add. More interesting for me will be which of the new pets is goind to be the most popular and the most often used.
It's not only my opinion that in MoP the BM hunters are the best choice for PVP and maybe even for PVE.But the two new BM pets (Quilen and Water Strider) are not very useful in PVP , I wonder what will be the most common pet from the other new...
Here is a?brief info about all of them again. I hope that you will tell me what will be your choice in the comments below :)
Basilisk
Tenacity Pet Many colors and Azeroth tames, in addition to Pandaria ones. Special Ability: ?Petrifying Gaze. Petrifies the target, reducing movement, attack and casting speed by 10%. The target will be petrified at 5 stacks, stunning them for 5 sec.
Crane
Cunning Pet 7 colors Special Ability: ?Lullaby. Puts the target to sleep for 4 sec. Bonus Ability: ?Trick. You command your Crane to do a trick.
Goat
Ferocity Pet 5 colors Special Ability: ?Trample. Your goat tramples the enemy, kicking up an obscuring cloud of dust, causing all enemies within 10 yards to have their spell cast speed increased by 50% (25% on player targets) for 30 sec.
?Porcupine
Tenacity Pet 6 colors Special Ability: ?Paralyzing Quill. Fires paralyzing quills around the porcupine, incapacitating all enemies for 2 sec. Bonus Ability: ?Rest. You command your pet Porcupine to take a rest.
Quilen
Exotic Pet, Tenacity 6 colors Exotic Ability: ?Eternal Guardian. Returns the spirit to the body, restoring a dead target to life with 60% health and 20% mana. Special Ability: ?Fearless Roar. The quilen lets out a fearless roar, increasing the critical strike chance of all party and raid members by 5% for 2 min.
?Water Strider
Exotic Pet, Cunning 4 colors Exotic Ability: ?Still Water. Infuses all party and raid members within vision with still water, increasing their spell power by 10% and their critical strike chance by 5%. Exotic Ability: ?Surface Trot. Allows the Hunter and the Water Strider to walk across water for 10 min. Any damage will cancel the effect.
At the conclusion of Raw last Monday, many in the WWE Universe were shocked to see WWE Champion CM Punk, moments after completing his brutal assault on John Cena, driven away from the scene of his attack by Paul Heyman. (WATCH) The mastermind of the Original ECW is best known in WWE circles as the man who brought Brock Lesnar to WWE 10 years ago, and to this day remains Lesnar?s advisor. What most don?t realize, however, is that as the leader of WWE?s reincarnation of ECW in June 2006, Heyman was also responsible for giving Punk his opportunity to debut on WWE TV in New York City and receive a standing ovation and "CM Punk" chants.
Simply put, Punk was "a Paul Heyman guy" long before he debuted in WWE?s ECW. After years of competing in independent promotions and building a reputation as a tough-as-nails non-conformist, Punk was signed to a WWE developmental contract and assigned to Louisville, Ky., home of then-WWE developmental promotion Ohio Valley Wrestling. It was then and there that Paul Heyman ? who at that point was creating future Superstars for WWE ? immediately formed the opinion that Punk had the "it" factor.
Punk looked nothing like WWE main-eventers of the time, which included Cena, Randy Orton, The Undertaker and Triple H. Yet Paul Heyman stuck to his convictions. He had always stated that "talent is talent, size is not talent, and a competitor need not both to be World Champion." Heyman took that same approach when he recruited Mexican free agents Eddie Guerrero and Rey Mysterio for the Original ECW. These two future WWE World Champions were deemed too small by WWE in the mid-1990s, until they eventually proved that everyone was incorrect. That is, everyone but Paul Heyman.
Fast forward to July 11, 2011, and the infamous "pipe bomb" promo that CM Punk detonated live on Monday Night Raw. Fearlessly shooting straight, Punk unleashed his opinions of WWE?s top stars like John Cena, as well as WWE owners, the McMahon family. In the middle of an unforgettable tirade that ended only because WWE cut his microphone, Punk proudly declared, "I?m a Paul Heyman guy." (WATCH) He did this because Heyman?s multiple disagreements with WWE management over the years had made him persona non grata, and Punk knew that pledging his allegiance to Heyman would further enrage the establishment.
Proving the adage that you can never say "never" in wrestling and WWE, when Paul Heyman returned to WWE as Brock Lesnar?s legal representative last May, it was @CMPunk who broke the news to the world via Twitter, proclaiming to his 1 million followers:
Okay. I'm having a blast with this. Here he is. The man. MY man. And he's headed to the ring....
With Brock Lesnar once again gone from WWE after successfully completing his mission of breaking Triple H?s arm and making him tap out at SummerSlam, it?s evident that Paul Heyman needs an outlet for his insatiable thirst to create anarchy. Who better to latch himself on to than CM Punk, an old friend who wants to earn respect while tearing down the WWE establishment ? and doing so as the WWE Champion, no less?
Live from the Artists Den Season: 5 Episode: 1 To celebrate the release of Little Broken Hearts, Norah Jones taped an episode of Live from the Artists Den at Brooklyn?s historic Green Building. The former brass foundry provided a spectacular backdrop for a 20-song retrospective of Jones?s career. Ranked 3.60 / 5 | 1 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Norah Jones Norahjones Miriam Happy Pills Little Broken Hearts Intimate Acoustic Artists Den Artistsden Brooklyn Green Building Music Live From The Artists Den Categories: Entertainment Music & Dance
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Mara Aye Te Mara Sahi Yaar Jo Hai..Song. Baby Fareeha Perform in Eid SHOW - Sandal Bar TV Faisalabad
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Portal 2 Ending Song "Want You Gone" With Download Link! -)
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ENIGMA MMX Social Song / First Version Official
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How to Copyright a Song
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Click here to watch the video (02:01) Submitted By: Howcast Tags: HotHowTos Performing Arts Music Copyright Songs Singing Legal Paperwork Rights Register Categories: How To
Together (A Song for Haiti)
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How To Get Into a Performing Arts High School
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Pirates of the Caribbean Theme Song
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Jeevan Tv 2 Cr Apple Mega Show Mappila Song Aswani
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Naaka Mukka Full Song 03 : Kadhalil Vizhunthen Original Video Release MALE VOCALS
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Click here to watch the video (05:07) Submitted By: Metacafe Affiliate U Tags: Advertising Arts Commercials Film Kadhalil Makka Mukka Mukku Naaka Naaku Nakka News Original Performing Release Short Superhit Tamil Trailers Tv Vizhunthen Web Series Categories: Entertainment
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Kash Koi - Song from HUM HAIN RAHI PYAR KE
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3yr Old Sings Song from Titanic! (My Heart Will Go On)
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Bruce Lee Music Video- the Song ``Remember`` by AJ Johnson
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i wish my pc could do that! Ranked 4.29 / 5 | 563459 views | 102 comments
Click here to watch the video (04:43) Submitted By: livermool Tags: Computers Program Categories: Science & Tech
This is Definitely Not an Apple Computer !
Check out the new safety features on the new Lenovo laptop...The levatating Chitty Chitty Comp Comp. Ranked 4.26 / 5 | 343185 views | 50 comments
Click here to watch the video (00:26) Submitted By: Utehchan Tags: Computers Drop Flying Ads Commercials Lenovo Categories: Cool Commercials Science & Tech
Opening Act Season: 1 Episode: 8 Von meets with a life coach to hash out his personal struggles with loved ones. Hear what seems to be holding him back. Ranked 3.60 / 5 | 1 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Music Family Opening Act Gaga Von Celebrity And Gossip Categories: Entertainment
Watch What Happens Live - After Show: Life Lessons from Reese Witherspoon Season: 6
Watch What Happens Live Season: 6 Episode: 55 Part II: Chris talks about his early start to fame and Tori names her HW babysitter and crush. Ranked 3.60 / 5 | 12 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Watch What Happens Live Season 6 After Show Episode 55 Tori Spelling Chris Klein Andy Cohen Reality And Game Shows Categories: Entertainment
Shooting Lessons
From the movie The Assassin Next Door - Galia (Olga Kurylenko) takes Elinor (Ninette Tayeb) to the roof to practice shooting under cover of rain and thunder. Ranked 4.00 / 5 | 23 views | 0 comments
Click here to watch the video (01:26) Submitted By: MovieClips.com Tags: Olga Kurylenko The Assassin Next Door MovieClips.com Categories: Entertainment
Khloe & Lamar - Life Lessons Season: 1
Khloe & Lamar Season: 1 Episode: 6 When Lamar meets a young man battling bone cancer, it forces him to reflect on his own life and relationships. Ranked 3.60 / 5 | 68 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Khloe And Lamar Khloe Kardashian Khloe Kardashian Odom Lamar Odom Los Angeles Lakers Marriage Newlyweds Kardashians Rob Kardashian Robert Kardashian Jr. Reality And Game Shows Khloe & Lamar Categories: Entertainment
Inuktitut Lessons
From the movie The Snow Walker - Kanaalaq (Annabella Piugattuk) teaches Charlie (Barry Pepper) some words in Inuktitut, along with how to hunt and fish. Ranked 4.00 / 5 | 34 views | 0 comments
Click here to watch the video (01:57) Submitted By: MovieClips.com Tags: Annabella Piugattuk Barry Pepper The Snow Walker MovieClips.com Categories: Entertainment
The Colgate Comedy Hour with Abbott & Costello - Singing Lessons Season: 5
Click here to watch the video (00:00) Submitted By: hulu Tags: Act Sketches Physical Comedy Word Play Vaudville Live Singing Tone Notes Falls The Colgate Comedy Hour With Abbott & Costello Categories: Comedy Entertainment
The Colgate Comedy Hour with Abbott & Costello - Dance Lessons Season: 3
The Colgate Comedy Hour with Abbott & Costello Season: 3 Episode: 17 Abbot and Costello go to France to get Costello dance lessons. Ranked 3.60 / 5 | 44 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Act Sketches Physical Comedy Word Play Vaudville Live Audience French Dance The Colgate Comedy Hour With Abbott & Costello Categories: Comedy Entertainment
Keeping Up with The Kardashians - Lessons from Bruce Season: 5
Keeping Up with The Kardashians Season: 5 Episode: 12 Is Scott ready to put an end to his out-of-control behavior? See if Bruce can talk some sense into this bad boy. Ranked 3.60 / 5 | 51 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: E! E! Shows Keeping Up With The Kardashians Kim Kardashian Reggie Bush Miles Austin Reality And Game Shows Keeping Up With The Kardashians Categories: Entertainment
Click here to watch the video (01:02) Submitted By: robert081 Tags: Amazing Crazy Humor Funny Jokes Entertainment Pets Animals Cats Dogs Categories: Comedy Pets & Animals
InfoMania - Lessons in Make-Up Season: 3
infoMania Season: 3 Episode: 28 Brett Erlich searches the Internet far and wide to bring you the best web videos on make-up. He gets caught up in the excitement and pretties himself up in the process. Ranked 3.60 / 5 | 24 views | 0 comments
Click here to watch the video (00:00) Submitted By: hulu Tags: Brett Erlich Viral Video Film School Makeup Tutorial Makeup Michelle Phan Bubzbeauty Makeup Hauls Haulers Lady GaGa Comedy Entertainment Current TV InfoMania Categories: Comedy Entertainment
Total From Bad Boy Ent. at Vocal Lessons
TOTAL FROM BAD BOY ENTERTAINMENT AT VOCAL LESSONS IN NYC. CRAZY JOINT Distributed by Tubemogul. Ranked 2.21 / 5 | 44 views | 0 comments
Click here to watch the video (02:02) Submitted By: kellytv09 Tags: TOTAL FROM BAD BOY ENTERTAINMENT AT VOCAL LESSONS IN NYC KELLY TV KELLYS HIP HOP SHOW Categories: Music & Dance
Chess.com: Beauty and Entertainment 2
More once-in-a-lifetime positions brought to Chess.com by GM Dzindzichashvili. Watch doubled passed pawns defeat a rook and a knight and that's just the first offering. Beautiful and entertaining chess from real game situations that will amaze any chess lover. Ranked 4.86 / 5 | 60 views | 0 comments
Click here to watch the video (03:53) Submitted By: chesscom Tags: Chess.com Playing Learning Video Lessons Chess Openings Clubs Online Analysis Tactics Combination Categories: How To
Chess.com: Beauty & Entertainment I
In a lifetime of chess love, GM Dzindzichashvili has seen thousands of incredible and beautiful positions. In this video, he distills a handful of the absolutely most amazing positions he has ever encountered. A pure delight to see, for players of any level! Ranked 3.55 / 5 | 162 views | 0 comments
Click here to watch the video (04:08) Submitted By: chesscom Tags: Chess Chess.com Playing Learning Video Lessons Openings Clubs Online Categories: How To
THE SPECTACULAR SPIDER-MAN: VOLUME 2: Movie Trailer
In the action-packed THE SPECTACULAR SPIDER-MAN: VOLUME 2, Peter Parker?s ability to tackle an onslaught of menacing super-villains is put to the ultimate test. He must take on the evil likes of some of his most daunting rivals ever -- the Shocker, Sandman and Rhino, all while finding time for his Chemistry lessons. Ranked 3.13 / 5 | 16584 views | 1 comments
Click here to watch the video (01:25) Submitted By: videodetective Tags: The Spectacular Spider-man: Volume 2 Family Sony Pictures Home Entertainment Movie Trailers Movie Trailer Movie Trailers Categories: Entertainment
The Soup - Lessons on LiLo Season: 5
The Soup Season: 5 Episode: 42 Sorry gals, Lindsay Lohan might not be over men after all! Find out what you need to know to prepare for her big switch. Ranked 3.60 / 5 | 25 views | 0 comments
Click here to watch the video (01:17) Submitted By: hulu Tags: The Soup Joel McHale Cable Box Digital Tv Celebrity And Gossip Categories: Entertainment
Dr. 90210 - Love Lessons Season: 5
Dr. 90210 Season: 5 Episode: 7 Dr. Matlock goes out on a blind date, but how will his new lady friend feel when he starts hitting on the main course? Ranked 3.60 / 5 | 91 views | 0 comments
Click here to watch the video (02:53) Submitted By: hulu Tags: Dr. 90210 Matlock Naked Sushi Models Reality And Game Shows Categories: Entertainment
LINDY HOP LESSON - Nick & Carla
Small Workshop with Nick Williams & Carla Heiney in Dortmund/Germany (10/2008). Ranked 4.50 / 5 | 374 views | 0 comments
Click here to watch the video (02:46) Submitted By: Metacafe Affiliate U Tags: Lindy Hop Swing Dancing Workshop Lessons Lindypott Colibri Entertainment Categories: Entertainment
Master Hobo Martial Arts Lessons
Master Hobo will teach you all the moves you need to know about to kick peoples asses all over the place who needs Chuck Norris , john claude vandam , steven seagal. Master Hobo kung fu is way better then these losers He biger then WrestleMania XXIV and the America's Best Dance Crew JabbaWockeez LOL Ranked 2.83 / 5 | 1326 views | 0 comments
Click here to watch the video (01:09) Submitted By: Shonuf79 Tags: Chuck Norris Steven Seagal John Claude Vandam Master Hobo Arnold Kick Ass Obama Clinton Of Call Of Duty World Wrestling Entertainment Vegas Tna Categories: Comedy Entertainment
Bachata Dance Class - Advanced Learners Level
Some sensual Santo Domingo dance steps and moves explained and shown by Marco and Sara of Salsa School - Italy. Though the language is Italian, dance, as music, has its own communication power that transcends language barriers! Ranked 4.48 / 5 | 69758 views | 0 comments
Click here to watch the video (01:10) Submitted By: salsaschool Tags: Bachata Lessons Class Dance Categories: Entertainment Music & Dance
Dave Celentano (from Guitar Tricks Video - Intro)
Dave Celentano is one of the industries hottest and most sought-after guitar instructors and has been teaching for over 20 years. Dave is proficient in many styles of music including rock, blues, heavy metal, jazz and classical, and specializes in multi-finger tapping, sweep picking, music theory, and reading music. Having published over 30 books, videos, DVDs, and albums, Dave has a prolific creative output unseen by most of todays published guitarists. Some of Dave's credits are: - Musician Institute graduate (G.I.T.), 1986 - Commissioned by Star Licks Video Company to write and perform in 7 instructional videos including "Randy Rhoads Style", " Eric Clapton Style" and "Guitar Tricks" -Guitar World (Jan. 04) listed Dave's Best of the Allman Brothers Signature Licks instructional DVD as one of the top seventy five essential guitar DVDs. Gear: Dave uses Gibson Les Pauls, Ibanez Jem, Fender Strat, WRC (Wayne Richard Charvel), GHS strings, Rocktron Black Cat Moan wah-wah, Roland amps, Fender amps, Ibanez Tube Screamer, MXR Phase 90, Uni-Vibe, and Jim Dunlop Jazz III picks Check out more of Dave Celentano at www.myspace.com/DaveCelentano or at www.DaveCelentano.com. Ranked 4.29 / 5 | 1261 views | 0 comments
Click here to watch the video (00:45) Submitted By: Metacafe Affiliate U Tags: Dave Celentano Rock Music Guitar Instructional Lessons Entertainment Categories: Music & Dance
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Public release date: 10-Sep-2012
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